Sunday, January 17, 2021

Prospect of SARS-CoV-2 spike protein: Potential role in vaccine and therapeutic development


Paper at NIH here.

28 proteins, including ofc the Spike:

The viral genome of the coronavirus encodes four structural proteins named spike (S), envelope (E), membrane (M), and nucleocapsid (N), 16 non-structural proteins (nsp1–16), and 8 accessory proteins. The S protein plays the most critical role in viral attachment, fusion, and entry into the target cell

mRNA gets a mention but not much else... this is it:

mRNA has been used as a template for endogenous expression of proteins selected as a vaccine candidate. An mRNA vaccine is a promising alternative because of its high potency, short production cycle, and low manufacturing cost. (Pardi et al., 2018; Yun et al., 2020). Currently, there is no mRNA vaccine in the market, so it will be challenging to pass the quality control and safety evaluation. Currently, mRNA-1273, a potential vaccine against SARS-CoV-2 based on encoding for a prefusion stabilized form of the S protein, has been selected for evaluation by Moderna in collaboration with investigators at the NIAID Vaccine Research Center (VRC). This vaccine is currently the focus of a Phase 1 clinical trial (NCT04283461). Several other companies are also developing mRNA vaccines against SARS-CoV-2 (Table 5 ).

mRNA vaccines are now current the only type of vaccines being administered in the US...

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